1. Prevalence of Azoospermia Factor (AZF) Deletions in Idiopathic Infertile Males in North-East India
ABSTRACT The Y-chromosome harbors about 107 genes and pseudo genes. Microdeletions of the Y-chromosome long arm are the most commonmutations in infertile males, where they involve one or more “azoospermia factors” (AZF a, b, and c). 100 consecutive infertile men were studied for AZF microdeletions by isolating Genomic DNA from peripheral blood and Polymerase Chain Reaction was carried with Genes: RBMY [RNA-binding motif (RBM), Y chromosome], BPY-2 (Testis-specific basic protein Y 2), STS markers: SY-84, SY-254. Out of 100 infertile males, five males exhibited AZF deletions. RBMY deletion was observed in one male, SY-84 deletion was observed in two males and SY-254 deletion was observed in two males. BPY-2 deletion was not observed in any of the males.
2. Microdeletions in the Y-chromosome of infertile males with Azoospermia, Oligozoospermia and Asthenozoospermia from Assam, India
3. Association of Oxidative Stress Biomarkers and Antioxidant Enzymatic Activity in Male Infertility of North-East India
The aimed study for fi nding the association of oxidative stress biomarkers; the Lipid and Protein peroxidation and antioxidant enzymes as Superoxide dismutase and Glutathione peroxidase activity in male infertility showed positive correlation between the stress biomarkers and antioxidant enzyme activity in the studied population of normozoospermic and infertile group.